Interpretation of 11C–choline PET/CT for the diagnosis of local relapse in radically treated prostate cancer

• DOI: 10.1186/s41824-017-0007-x
• Publication Date: 2017-10-11T08:45:45Z
• Authors: A. Matti; G. M. Lima; L. Zanoni; C. Pultrone; R. Schiavina; F. Lodi; S. Fanti; C. Nanni
• Keywords: PET-CT

11C-choline PET/CT is a widely-used tool for the diagnostic of prostate cancer (PCa). In literature, great variability local relapse (LR) detection rate reported. The aim this study to provide positivity criteria LR in patients who had surgery PCa and presented specific antigen (PSA) failure.Sixty radically treated presenting PSA failure were retrospectively analysed. Two Nuclear Medicine Physicians revised scans defined by consensus if even mild focal uptake was present bed (PB) bladder-urethral junction (BUJ) along midline, regardless previous report results.The results subsequently correlated with clinical radiological follow up (FU) 1 2 year TNM staging, Gleason score (GS), level at relapse, radiotherapy (RT) hormone therapy (HT) after surgery.There 22/60 patients; 11 them true positive false positive. showed tight connection positivity/negativity Choline scan. Most cases (10/11 patients) ≥ ng/ml, while approximately half (5/11 below ng/ml. other variables not LR.This shows that an PB BUJ midline must be considered suspicious PCa, especially they are >