Liver resection of hepatocellular carcinoma in HIV-HCV co-infected patients: a retrospective case series

• DOI: 10.1186/s43066-022-00215-x
• Publication Date: 2022-09-12T04:04:50Z
• Authors: Francesco Cammarata; Laura Benuzzi; Michele Crespi; Albert Troci; Luca Pennacchi; Monica Schiavini; Diego Foschi
• Keywords: Hepatitis C

Abstract Introduction Despite the effectiveness of new therapies and awareness campaigns, number seropositive patients is increasing every year. Recently, other causes death, not directly related to HIV, have emerged, such as chronic liver disease. The risk hepatocellular carcinoma (HCC) seven times greater in HIV than noninfected patients, it especially attributable HCV infection. aim our study was evaluate clinical outcomes HCC HIV-HCV co-infected after resection (LR). Materials methods current conducted on a prospective database reviewed retrospectively. All consecutive with treated by LR from January 2013 March 2019 at Luigi Sacco University Hospital Milan were enrolled. We included older 18 years age HCV-related HCC, this set we identified two groups based presence Results 16 infection precisely five co-infection eleven alone. male against 72.7% non-HIV group ( p = 0.509). had optimal virologic control normal CD4 T-cell count. mean diagnosis-to-treatment interval statistically different between (HIV versus non-HIV: 1.2 ± 0.55 months 2.39 1.09 months, 0.039). No significant differences found HCV-infected patients. Long-term terms OS RFS similar groups. Conclusions With multidisciplinary approach intensive support, can be safe efficacious procedure For these reasons, should exclude potential merely basis their seropositivity.