Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage

• DOI: 10.1189/jlb.0209082
• Publication Date: 2009-10-21T00:34:24Z
• Authors: Woong-Ki Kim; Yue Sun; Hien Do; Patrick Autissier; Elkan F Halpern; Michael Piatak; Jeffrey D Lifson; Tricia H Burdo; Michael S McGrath; Kenneth Williams
• Keywords: CD16; Monocyte; Pathogenesis; Simian immunodeficiency virus; Viremia

Abstract Expansion of two monocyte subpopulations expressing CD16 and their correlation with viral load are observed in this cross-sectional study SIV-infected macaques. Infection by HIV is associated the expansion monocytes antigens, but significance pathogenesis largely unknown. In rhesus macaques, at least three blood were identified based on expression CD14 CD16: CD14highCD16−, CD14highCD16low, CD14lowCD16high. The phenotypes functions these subpopulations, including CD16+ monocytes, investigated normal, uninfected macaques that infected SIV or chimeric SHIV. To assess whether different expand contract AIDS pathogenesis, we conducted a 54 SIV- SHIV-infected 48 controls. absolute numbers populations examined acutely animals, chronically animals no detectable plasma virus RNA, died AIDS. CD14highCD16low CD14lowCD16high elevated significantly RNA compared Moreover, significant, positive was evident between number cohort. These data show dynamic changes most notably, during lentiviral infection, which specific to disease stage.