Interferon-γ stimulates the expression of galectin-9 in cultured human endothelial cells

• DOI: 10.1189/jlb.72.3.486
• Publication Date: 2022-09-28T01:38:14Z
• Authors: Tadaatsu Imaizumi; Mika Kumagai; Naoko Sasaki; Hidekachi Kurotaki; Fumiaki Mori; Masako Seki; Nozomu Nishi; Koji Fujimoto; Kunikazu Tanji; Takeo Shibata; Wakako Tamo; Tomoh Matsumiya; Hidemi Yoshida; Xue-Fan Cui; Shingo Takanashi; Katsumi Hanada; Ken Okumura; Soroku Yagihashi; Koichi Wakabayashi; Takanori Nakamura; Mitsuomi Hirashima; Kei Satoh
• Keywords: Galectin

Abstract Galectin-9 is a member of the galectin family and has been identified as an eosinophil chemoattractant produced by activated T lymphocytes. Vascular endothelial cells play important role in initial step recruitment activation immune inflammatory responses. We have addressed stimulation galectin-9 expression cells. was detected membrane cytosolic fractions human umbilical vein stimulated with interferon-γ (IFN-γ). IFN-γ also enhanced adhesion eosinophilic leukemia-1 to monolayers, it inhibited presence lactose. Interleukin-4, which induces eotaxin expression, did not affect galectin-9. The situ endothelium from patients diseases found express IFN-γ-induced production may responses regulating interactions between vascular wall eosinophils.