Risk factors for acute kidney injury following coronary artery bypass graft surgery in a Chinese population and development of a prediction model.

• DOI: 10.11909/j.issn.1671-5411.2021.09.011
• Publication Date: 2021-09-28
• Authors: Yang Li; Xuejian Hou; Tao-Shuai Liu; Shijun Xu; Zhuhui Huang; Pengyun Yan; Xiaoyu Xu; Ran Dong
• Keywords: Derivation

Acute kidney injury (AKI) after coronary artery bypass graft (CABG) surgery is associated with significant morbidity and mortality. This retrospective study aimed to establish a risk score for postoperative AKI in Chinese population.A total of 1138 patients undergoing CABG were collected from September 2018 May 2020 divided into derivation validation cohort. was defined according the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Multivariable logistic regression analysis used determine independent predictors AKI, predictive ability model determined using receiver operating characteristic (ROC) curve.The incidence cardiac surgery-associated acute (CSA-AKI) 24.17%, 0.53% required dialysis (AKI-D). Among cohort, multivariable showed that age ≥ 70 years, body mass index (BMI) 25 kg/m2, estimated glomerular filtration rate (eGFR) ≤ 60 mL/min per 1.73 m2, ejection fraction (EF) 45%, use statins, red blood cell transfusion, adrenaline, intra-aortic balloon pump (IABP) implantation, low output syndrome (LCOS) reoperation bleeding predictors. The scored 0 32 points three categories. frequencies as follows: 0-8 (15.9%), 9-17points (36.5%) 18 (90.4%). area under ROC curve 0.730 (95% CI: 0.691-0.768) had good discrimination an 0.735 0.655-0.815). well calibrated Hosmer-Lemeshow test (P = 0.372).The performance prediction valid accurate predicting KDIGO-AKI patients, could improve early prognosis clinical interventions.