Leucocyte depletion in cardiopulmonary bypass: a comparison of four strategies

• DOI: 10.1191/0267659103pf649oa
• Publication Date: 2003-06-26T01:06:18Z
• Authors: Piya Samankatiwat; Ioannis Samartzis; Panuwat Lertsithi...; Demetrios Stefanou; Prakash P Punjabi; Kenneth M Taylor; Terence Gourlay
• Keywords: Discontinuation; Lactoferrin

Leucocytes have been shown to play a fundamental role in the pathophysiology of inflammation. This prospective, randomized, controlled study was designed identify most advantageous leucocyte depletion technique terms reduction systemic inflammatory response syndrome and myocardial ischaemia reperfusion injury associated with cardiopulmonary bypass (CPB). Forty consecutive patients undergoing elective coronary artery graft (CABG) surgery were randomly allocated one four groups. The groups consisted control group, (SLD) cardioplegic (CLD) group total (TLD) group. There 10 each Lactoferrin (marker neutrophil activation) troponin-I injury) measured at six time points: post induction, 5 min on CPB, before releasing aortic crossclamp, 15 after clamp 1 24 hours discontinuation CPB. Plasma lactoferrin levels increased rapidly every commencement subsequently reached peak crossclamp gradually declined lowest concentration observed TLD (range 2.15-141.9 ng/mL) CLD (7.469-114.6 ng/mL). Regarding injury, plasma cardiac did not differ significantly between groups; but concentrations rose dramatically all Nevertheless, had level (1.37-5.55 In conclusion, it is believed that probably major contributor response. Although there no clear statistical significance this pilot study, data tend support strategy as optimal method for attenuating activation injury.