Excess mortality in depressive and anxiety disorders: The Lifelines Cohort Study

• DOI: 10.1192/j.eurpsy.2021.2229
• Publication Date: 2021-08-31T08:30:57Z
• Authors: R. C. Oude Voshaar; I. Aprahamian; M. K. Borges; R. H. S. van den ...; R. M. Marijnissen; E. O. Hoogendijk; B. van Munster; H. W. Jeuring
• Keywords: Depression

Abstract Background To examine the mortality risk of current and life-time depressive as well anxiety disorders, whether this is moderated by sex or age, can be explained lifestyle and/or somatic health status. Methods A cohort study (Lifelines) including 141,377 participants (18–93 years) which were followed-up regarding for 8.6 years (range 3.0–13.7). Baseline disorders according to Diagnostic Statistical Manual Mental Disorders, fourth edition criteria assessed with Mini International Neuropsychiatric Interview lifetime diagnoses self-report. All-cause was retrieved from Statistics Netherlands. Cox-regression applied calculate proportional hazard ratios, adjusted (physical activity, alcohol use, smoking, body mass index) status (multimorbidity frailty) in different models. Results The rate conditional upon age but not on sex. Only people below 60 years, associated mortality. disorder panic independently predicted when all mental included simultaneously one overall model (hazard ratio [HR] = 2.18 [95% confidence intervals (CI): 1.56–3.05], p < 0.001 HR 2.39 CI: 1.15–4.98], 0.020). Life-time however, independent each other Associations hardly changed characteristics decreased substantially (in particular physical frailty). Conclusions In particular, excess their lifestyle. This effect seems partly multimorbidity frailty, suggest that chronic disease management depression-associated morbidity needs (further) improved.