Exploring the association between brain-derived neurotrophic factor (BDNF) levels and longitudinal psychopathological and cognitive changes in Sardinian psychotic patients

• DOI: 10.1192/j.eurpsy.2022.414
• Publication Date: 2022-09-02T06:49:51Z
• Authors: U. Isayeva; M. Manchia; D. Primavera; L. Deriu; E. Caboni; N. Iaselli; D. Sundas; M. Tusconi; R. Collu; M. Scherma; A. Squassina; D. Congiu; W. Fratta; P. Fadda; B. Carpiniello
• Keywords: schizophrénia; Psychiatry; 03 medical and health sciences; 0302 clinical medicine; bdnf; RC435-571; biomarker; Psychosis; Abstract; 3. Good health

Introduction Schizophrenia spectrum disorders are among the most debilitating mental and evidence on its pathophysiological underpinnings is scant. The brain-derived neurotrophic factor (BDNF) appears to be involved in pathophysiology of these complex psychiatric disorders. Objectives present study investigates longitudinal variation serum BDNF levels a 24-month observational cohort Sardinian psychotic patients (LABSP). This assessed relationship with psychopathological cognitive changes. Further, we also examined if genetic variations within gene could moderate relationships. Methods Every six months 105 LABSP were for their levels, as well series psychopathological, cognitive, drug-related measures. Four tag single nucleotide polymorphisms (SNPs) selected analyzed using Polymerase Chain Reaction (PCR). Longitudinal data mixed-effects linear regression models (MLRM). Results Analysis showed significantly lower peripheral depressive negative symptoms. decreased scoring measures such symbol coding semantic fluency. In addition, Val66Met polymorphism moderated between severity symptoms levels. Conclusions Our findings consistent previous literature suggesting that associated some domains mood disruption major psychosis. results suggest lack association variants, except polymorphism, Disclosure No significant