Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomized controlled trial

• DOI: 10.1192/j.eurpsy.2023.832
• Publication Date: 2023-08-08T09:11:35Z
• Authors: I. Husain; M. Umer; M. Asif; A. Bukhsh; T. Kiran; M. Ansari; H. Aslam; M. Bhatia; F. Dogar; O. Husain; H. A. Khan; A. A. Mufti; B. Mulsant; F. Naeem; H. A. Naqvi; C. De Oliveria; S. Siddiqui; A. Tamizuddin; W. Wang; J. Zaheer; N. Husain; N. Chaudhry; I. Chaudhry
• Keywords: Psychoeducation

Introduction Bipolar disorder (BD) is a source of marked disability, morbidity, and premature death. There paucity research on personalized psychosocial interventions for BD, especially in lowresource settings. A previously published pilot randomized controlled trial (RCT) Culturally adapted PsychoEducation (CaPE) intervention BD Pakistan reported higher patient satisfaction, enhanced medication adherence, knowledge attitudes towards improvement mood symptom scores health-related quality life measures compared to treatment-as-usual (TAU). Objectives This protocol describes larger multicentre RCT confirm the clinical cost-effectiveness CaPE Pakistan. Methods individual, parallel arm, 300Pakistani adults with BD. Participants over age 18, adiagnosis bipolar I II who are currently euthymic, will berecruited from seven sites including Karachi, Lahore, Multan, Rawalpindi,Peshawar, Hyderabad Quetta. Time recurrence be primaryoutcome assessed using Longitudinal Interval Follow-up Evaluation(LIFE). Secondary include symptomatology, qualityof functioning, adherence psychotropic medications, andknowledge Results Full ethics approval has been received National Bioethics Committee (NBC) Centre Addiction Mental Health (CAMH), Toronto, Canada. The study completed sixty-five screening across centres, which forty-eight participants have randomised. Conclusions successful lead rapid implementation practice, not only Pakistan, but also other low-resource settings those high-income countries, improve outcomes, social occupational South Asian minority patients Disclosure Interest None Declared