Early Neuroleptic Intervention in Schizophrenia: Are Prodromal Symptoms Valid Predictors of Relapse?

• DOI: 10.1192/s0007125000292416
• Publication Date: 2018-08-06T23:09:27Z
• Authors: W. Gaebel; U. Frick; W. Köpcke; M. Linden; P. Müller; F. Müller-Spahn; A. Pietzcker; J. Tegeler
• Keywords: Prodrome; Prodromal Stage

All recently completed controlled two-year studies on intermittent, early neuroleptic intervention treatment have failed to compare favourably with maintenance concerning relapse prevention. The reason for this failure is still unclear. Therefore the implicit, but as yet unproven, hypothesis that a can be predicted from prodromal symptoms was tested perspective of our German multicentre study. Results demonstrate not case. Possible reasons and clinical implications negative finding are discussed.