A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases

• DOI: 10.1194/jlr.e500003-jlr200
• Publication Date: 2005-07-02T01:00:07Z
• Authors: Mary C. Hunt; Junji Yamada; Lois J. Maltais; Mathew W. Wright; Ernesto J. Podesta; Stefan E.H. Alexson
• Keywords: 0301 basic medicine; 570; Peroxisome Proliferator-Activated Receptors; Materials Science; QD415-436; coenzyme A; Biochemistry; 576; Mice; 03 medical and health sciences; Stereochemistry; Terminology as Topic; Biochemistry, Genetics and Molecular Biology; Materials Chemistry; Animals; Humans; Molecular Biology; Biology; 0303 health sciences; Macromolecular Crystallography Techniques; Nomenclature; Botany; peroxisomes; Life Sciences; Taxonomy (biology); Rats; Alternative Splicing; Chemistry; fatty acid metabolism; Palmitoyl-CoA Hydrolase; Multigene Family; Physical Sciences; Enzyme Structure; Molecular Mechanisms of Ras Signaling Pathways; acyl-CoA hydrolase; nomenclature; acyl-CoA thioesterase

Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding nomenclature these genes. In agreement with HUGO Gene Nomenclature Committee Mouse Genomic Committee, revised for mammalian thioesterases/hydrolases has been suggested 12 member family. The family root symbol ACOT, human genes named ACOT1-ACOT12, rat mouse Acot1-Acot12. Several ACOT result splicing events, splice variants cataloged.