HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity

• DOI: 10.1194/jlr.m059865
• Publication Date: 2015-08-08T01:01:45Z
• Authors: Mark S. Borja; Kit F. Ng; Angela Irwin; Jaekyoung Hong; Xing Wu; Daniel Isquith; Xue-Qiao Zhao; Bryan Prazen; Virginia Gildengorin; Michael N. Oda; Tomáš Vaisar
• Keywords: Efflux

HDL is the primary mediator of cholesterol mobilization from periphery to liver via reverse transport (RCT). A critical first step in this process uptake lipid-loaded macrophages by HDL, a function inversely associated with prevalent and incident cardiovascular disease. We hypothesized that dynamic ability undergo remodeling exchange apoA-I an important potentially rate-limiting aspect RCT. In study, we investigated relationship between HDL-apoA-I (HAE) serum (HDL-C) efflux capacity. compared HAE total ABCA1-specific capacity 77 subjects. found was highly correlated both (r = 0.69, P < 0.0001) 0.47, efflux, remained significant after adjustment for HDL-C or apoA-I. Multivariate models sterol indicated accounted approximately 25% model variance efflux. conclude remodel, as measured HAE, contributor capacity, independent apoA-I, indicating dynamics are factor likely