Carotid baroreceptor stimulation in obese rats affects white and brown adipose tissues differently in metabolic protection

• DOI: 10.1194/jlr.m091256
• Publication Date: 2019-05-24T22:45:13Z
• Authors: Quan Cao; Junxia Zhang; Qiao Yu; Jing Wang; Mingyan Dai; Yijie Zhang; Qiang Luo; Mingwei Bao
• Keywords: Adipose triglyceride lipase; PRDM16; Hormone-sensitive lipase; CD36

The sympathetic nervous system (SNS) regulates the functions of white adipose tissue (WAT) and brown (BAT) tightly. Carotid baroreceptor stimulation (CBS) efficiently inhibits SNS activation. We hypothesized that CBS would protect against obesity. administered to obese rats measured AMP-activated protein kinase (AMPK)/ PPAR pathway responses as well changes in perirenal WAT (PWAT), epididymal (EWAT), interscapular BAT (IBAT). alleviated obesity-related metabolic changes, improving insulin resistance; reducing adipocyte hypertrophy, body weight, weights; decreasing norepinephrine but increasing acetylcholine plasma, PWAT, EWAT, IBAT. also downregulated fatty acid translocase (CD36), transport (FATP), phosphorylated total hormone sensitive lipase, A, PPARγ rats. Simultaneously, upregulated triglyceride AMPK, PPARα However, differed; although many were more IBAT, CD36, FATP, PWAT EWAT. Overall, decreased chronically activated ameliorated disorders by regulating AMPK/PPARα/γ pathway.