Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population

• DOI: 10.1194/jlr.p049015
• Publication Date: 2015-02-04T03:51:23Z
• Authors: Lin Ding; An Song; Meng Dai; Min Xu; Wanwan Sun; Baihui Xu; Jichao Sun; Tiange Wang; Yu Xu; Jieli Lu; Weiqing Wang; Yufang Bi; Guang Ning
• Keywords: Prediabetes; Quartile; Lipoprotein particle; Lipoprotein(a); Hyperinsulinemia

Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the of CVD. However, relationship between T2D is poorly characterized, especially in Asian population. Therefore, we conducted cross-sectional study 10,122 participants aged 40 years or older Jiading District, Shanghai, China. Our found that prevalence was decreased from 20.9% to 15.0% lowest quartile highest concentrations (P trend <0.0001). Logistic regression analyses showed odds ratios 95% confidence intervals prevalent quartiles 2-4 versus 1 were 0.86 (0.73-1.01), 0.88 (0.75-1.04), 0.76 (0.64-0.90) = 0.0002), after adjustment traditional confounding factors. Moreover, risks prediabetes, insulin resistance, hyperinsulinemia also top quartile. This inverse association not appreciably changed adjusted hypoglycemic medications excluded subjects with and/or lipid-lowering agents history self-reported