The influence of placental metabolism on fatty acid transfer to the fetus

• DOI: 10.1194/jlr.p072355
• Publication Date: 2016-12-03T02:50:27Z
• Authors: Simone Perazzolo; Birgit Hirschmugl; Christian Wadsack; Gernot Desoye; Rohan M. Lewis; Bram G. Sengers
• Keywords: Fatty Acid Metabolism

The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental of nonesterified acids identify rate-determining processes. Isolated perfused human was uptake 13C-fatty release endogenous acids. Only 6.2 ± 0.8% maternal taken up by delivered fetal circulation. Of unlabeled released from lipid pools, 78 5% recovered in circulation 22 Computational indicated that metabolism necessary explain discrepancy between delivery Without metabolism, model overpredicts 15-fold. Metabolic rate predicted be main determinant microvillous membrane had greater transport capacity than basal membrane. suggests incorporation into pools may modulate their fetus. Future work needs focus on regulating pools.