Infusion of Human Umbilical Cord Blood Ameliorates Neurologic Deficits in Rats with Hemorrhagic Brain Injury

• DOI: 10.1196/annals.1334.009
• Publication Date: 2005-06-17T18:48:25Z
• Authors: ZHENHONG NAN; ANDREW GRANDE; CYNDY D. SANBERG; PAUL R. SANBERG; WALTER C. LOW
• Keywords: Cord blood

A bstract : Umbilical cord blood is a rich source of hematopoietic stem cells. It routinely used for transplantation to repopulate cells the immune system. Recent studies, however, have demonstrated that intravenous infusions umbilical can ameliorate neurologic deficits associated with ischemic brain injury in rodents. Moreover, infused penetrate into parenchyma and adopt phenotypic characteristics typical neural In present study we tested hypothesis administration also diminish caused by intracerebral hemorrhage (ICH). Intracerebral major cause morbidity mortality, at time there are no adequate therapies minimize consequences this cerebrovascular event. ICH was induced rats intrastriatal injections collagenase bleeding striatum. Twenty‐four hours after induction received saphenous vein human (2.4 × 10 6 3.2 cells). Animals were evaluated using battery tests day 1 ICH, but before blood, days 7, 14 (days 13, respectively, administration). These included neurological severity test, stepping an elevated body‐swing test. exhibited significant improvements (1) test 13 infusion comparison saline‐treated animals ( P < 0.05 ); (2) (3) 0.05). results demonstrate hemorrhage.