Strategies for Detecting Adverse Drug Events among Older Persons in the Ambulatory Setting
*Adverse Drug Reaction Reporting Systems
Drug-Related Side Effects and Adverse Reactions
Life Sciences
610
Medicare
Ambulatory Care Facilities
Medical Records
3. Good health
03 medical and health sciences
0302 clinical medicine
Pharmaceutical Preparations
Drug Toxicity
Geriatrics
New England
616
Medicine and Health Sciences
Adverse Drug Reaction Reporting Systems
Humans
Medication Errors
Health Services Research
Health Services Administration
Aged
DOI:
10.1197/jamia.m1586
Publication Date:
2004-08-07T00:13:41Z
AUTHORS (10)
ABSTRACT
To examine various strategies for the identification of adverse drug events (ADEs) among older persons in the ambulatory clinical setting.A cohort study of Medicare enrollees (n = 31,757 per month) receiving medical care from a large multispecialty group practice during a 12-month observation period (July 1, 1999 through June 30, 2000).Possible drug-related incidents occurring in the ambulatory clinical setting were detected using signals from multiple sources.During the tracking period, there were 1,523 identified ADEs, of which 421 (28%) were considered preventable. Across all sources, 23,917 signals were found; 12,791 (53%) were potential incidents that led to review of a patient's medical record and 2,266 (9%) were presented to physician reviewers. Although the positive predictive value (PPV) for reports from providers was high compared with other sources (54%), only 11% of the ADEs and 6% of the preventable ADEs were identified through this source. PPVs for other sources ranged from a low of 4% for administrative incident reports to a high of 12% for free-text review of electronic notes. Computer-generated signals were the source for 31% of the ADEs and 37% of the preventable ADEs. Electronic notes were the source for 39% of the ADEs and 29% of the preventable ADEs. There was little overlap in the ADEs identified across all sources.Our findings emphasize the limitations of voluntary reporting by health care providers as the principal means for detection of ADEs and suggest that multiple strategies are required to detect ADEs in geriatric ambulatory patients.
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