Pharmacologic rationale for regional drug delivery.

• DOI: 10.1200/jco.1984.2.5.498
• Publication Date: 2017-02-23T12:48:40Z
• Authors: J M Collins
• Keywords: Pharmacodynamics; Therapeutic index

Regional drug delivery is an approach designed to improve the selectivity of chemotherapy. When compared with systemic administration, regional can potentially increase concentrations at tumor sites and/or lower exposure. Pharmacokinetic analysis evaluate or even predict relative advantage delivery. Based on a quantitative delivery, some drugs and are more favorable than others. The formulas for therapeutic intraarterial, intrathecal, intraperitoneal have similar structure. ratio total body clearance its exchange rate principal determinant advantage. Thus, most circumstances use high clearances low rates. Pharmacodynamic factors must also be considered overall assessment