Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma.

• DOI: 10.1200/jco.1996.14.2.405
• Publication Date: 2017-02-24T09:46:37Z
• Authors: D Meitar; S E Crawford; A W Rademaker; S L Cohn
• Keywords: Histology; Vascularity; Univariate analysis

PURPOSE To determine if the clinical outcome of children with neuroblastoma (NB) is correlated degree tumor neovascularization and to assess relationship stage, N-myc copy number, histology angiogenesis. MATERIALS AND METHODS The vascularity primary untreated NB from 50 patients diagnosed at a single institution between 1984 1994 was evaluated. An image processor used analyze tissue area for each histologic slide tumor, vascular index (VI) calculated, where VI = total number vessels/mm2 area. Tumors were classified histologically according criteria Shimada et al (J Natl Cancer Inst 73:405-416, 1984), determined by Southern blot analysis. RESULTS We found that higher (> 4.0) in strongly widely disseminated disease (P .006) poor survival < .0001). more than 4.0 also statistically associated amplification .02) unfavorable .02). Univariate analysis demonstrated histology, predictive outcome. Cox regression showed provided independent prognostic information. CONCLUSION Our studies indicate angiogenesis may play an important role determining biologic behavior NB. Antiangiogenic therapy prove be effective treatment highly vascular,