Synovial Sarcoma: A Multivariate Analysis of Prognostic Factors in 112 Patients With Primary Localized Tumors of the Extremity

• DOI: 10.1200/jco.2000.18.10.2087
• Publication Date: 2017-02-24T09:23:15Z
• Authors: Jonathan J. Lewis; Cristina R. Anton...; Denis H. Y. Leung; David Blumberg; John H. Healey; James M. Woodruff; Murray F. Brennan
• Keywords: Neurovascular bundle; Synovial Sarcoma; Primary tumor; Log-rank test

PURPOSE: Synovial sarcoma is a high-grade tumor that associated with poor prognosis. Previous studies analyzing prognostic factors are limited because of inclusion heterogeneous cohorts patients nonextremity and recurrent tumors. The objective this study was to determine independent primary synovial localized the extremity. PATIENTS AND METHODS: Between July 1, 1982, June 30, 1996, 112 underwent surgical resection for cure at our institution then were followed-up prospectively. Clinical pathologic examined value included age, sex, site location, depth, size, microscopic status margins, invasion bone or neurovascular structures, monophasic biphasic histology. end points analyzed time first local recurrence not preceded by distant recurrence, any disease-related mortality. These modeled using method Kaplan Meier log-rank test Cox regression. RESULTS: median duration follow-up among survivors in cohort 72 months. 5-year local-recurrence, distant-recurrence, mortality rates 12%, 39%, 25%, respectively. Tumor size ≥ 5 cm (P = .001; relative risk [RR] 2.7; 95% confidence interval [CI], 1.5 5.2) presence .04; RR 2.3; CI, 1.0 5.3) adverse predictors recurrence. .003; 1.4 6.3) .03; 6.5) also CONCLUSION: natural history extremity related structures.