Recovery After Stem-Cell Transplantation for Hematologic Diseases

• DOI: 10.1200/jco.2001.19.1.242
• Publication Date: 2017-02-24T06:54:02Z
• Authors: Stephanie J. Lee; Diane Fairclough; Susan K. Parsons; Robert J. Soiffer; David C. Fisher; Robert L. Schlossman; Joseph H. Antin; Jane C. Weeks
• Keywords: Adult; Male; Health Status; Hematopoietic Stem Cell Transplantation; Recovery of Function; Middle Aged; Hematologic Diseases; Transplantation, Autologous; Disease-Free Survival; Statistics, Nonparametric; 3. Good health; Survival Rate; 03 medical and health sciences; Logistic Models; Treatment Outcome; 0302 clinical medicine; Activities of Daily Living; Quality of Life; Humans; Transplantation, Homologous; Female; Prospective Studies; Aged

PURPOSE: Although the number of autologous and allogeneic stem-cell transplantations (SCT) is increasing, relatively little information about recovery after transplantation available. Quantitative appropriate for patient counseling difficult to discern from literature. We sought suggest reasonable expectations symptoms SCT hematologic malignancies other disorders using following measures: (1) objective measures health status, such as frequency clinic visits, need rehospitalization, medication usage, work overall event-free survival; (2) qualitative assessment quality life, returning a normal resumption activities, satisfaction with appearance, whether has occurred; (3) quantification specific bothersome symptoms. PATIENTS AND METHODS: Autologous recipients at tertiary-care transplant center participated in prospective, longitudinal questionnaire study. RESULTS: Three hundred twenty patients were studied. Questionnaire response rates 6, 12, 24 months range 85% 88% among survivors. had better survival, fewer symptoms, more complete 6 months, these advantages largely equalized by 12 months. Specific reported less than 24% transplantation, except fatigue financial sexual difficulties, which prevalent. CONCLUSION: These findings may help counsel considering educate them recovery. Overall, low level continued through first year are encouraging.