Comparison of Breast Magnetic Resonance Imaging, Mammography, and Ultrasound for Surveillance of Women at High Risk for Hereditary Breast Cancer

• DOI: 10.1200/jco.2001.19.15.3524
• Publication Date: 2017-02-24T07:28:07Z
• Authors: E. Warner; D. B. Plewes; R. S. Shumak; G. C. Catzavelos; L. S. Di Prospero; M. J. Yaffe; V. Goel; E. Ramsay; P. L. Chart; D. E.C. Cole; G. A. Taylor; M. Cutrara; T. H. Samuels; J. P. Murphy; J. M. Murphy; S. A. Narod
• Keywords: Breast MRI; Breast ultrasound

PURPOSE: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes regular mammography clinical breast examination, although the effectiveness of these screening techniques in has not been established. The purpose present study was to compare magnetic resonance imaging (MRI) with ultrasound, mammography, physical examination women at high risk hereditary cancer. PATIENTS AND METHODS: A total 196 women, aged 26 59 years, proven or mutations strong family histories ovarian cancer underwent MRI, on a single day. biopsy performed when any four investigations judged be suspicious malignancy. RESULTS: Six invasive cancers one noninvasive were detected among high-risk women. Five occurred carriers, sixth woman previous history prevalence 96 6.2%. All six by all 1.0 cm less diameter, node-negative. In contrast, only three two examination. addition MRI more commonly available triad identified additional that would otherwise have missed. CONCLUSION: Breast may superior ultrasound