Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography

• DOI: 10.1200/jco.2002.20.2.379
• Publication Date: 2017-02-24T07:59:20Z
• Authors: Reinhard Bos; Jacobus J.M. van ...; Elsken van der Wall; Petra van der Groep; Paul J. van Diest; Emile F.I. Comans; Urvi Joshi; Gregg L. Semenza; Otto S. Hoekstra; Adriaan A. Lammer...; Carla F.M. Molthoff
• Keywords: Fluorodeoxyglucose; Standardized uptake value; Univariate analysis

PURPOSE: Variable uptake of the glucose analog 18 fluorodeoxyglucose (FDG) has been noticed in positron emission tomography (PET) studies breast cancer patients, with low occurring especially lobular cancer. At present, no satisfactory biologic explanation exists for this phenomenon. This study compared FDG vivo biomarkers expected to be involved underlying mechanisms. PATIENTS AND METHODS: Preoperative FDG-PET scans were performed 55 patients. activity was assessed visually by three observers using a four-point score. Tumor sections stained immunohistochemistry transporter-1 (Glut-1); Hexokinase (HK) I, II, and III; macrophages; hypoxia-inducible factor-1-alfa (HIF-1α); vascular endothelial growth factor (VEGF 165 ); microvessels. Mitotic index (MAI), amount necrosis, number lymphocytes, tumor cells/volume assessed. RESULTS: There positive correlations between Glut-1 expression (P < .001), MAI = necrosis .010), .009), HK I .019), lymphocytes .032), microvessel density (r .373; P .005). HIF-1α, VEGF , III, macrophages showed univariate correlation FDG. In logistic regression, however, HIF-1α II added value Glut-1. CONCLUSION: is function microvasculature delivering nutrients, transportation into cell, entering glycolysis, cells/volume, proliferation rate (also reflected necrosis), (not macrophages), upregulating Together, these features explain why cancers vary elucidate