Assessment of Coronary Heart Disease Morbidity and Mortality After Radiation Therapy for Early Breast Cancer

• DOI: 10.1200/jco.2002.20.4.1036
• Publication Date: 2017-02-24T08:46:55Z
• Authors: Katherine A. Vallis; Melania Pintilie; Nelson Chong; Eric Holowaty; Pamela S. Douglas; Peter Kirkbride; Andreas Wielgosz
• Keywords: Adult; Radiotherapy; Incidence; Myocardial Infarction; Breast Neoplasms; Middle Aged; Risk Assessment; Functional Laterality; 3. Good health; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Morbidity; Radiation Injuries; Aged

PURPOSE: To assess the risk of fatal and nonfatal myocardial infarction (MI) after breast-conserving surgery (BCS) radiation therapy (RT) for left-sided breast cancer. PATIENTS AND METHODS: A hospital-based retrospective cohort linkage study all cancer patients registered at Princess Margaret Hospital (PMH), Toronto, Canada, between 1982 1988 who were treated with postlumpectomy RT was performed. Available identifiers linked to two province-wide health files: Canadian Institute Health Information Hospitalization File Ontario Mortality Database. Admissions hospital MI deaths attributable identified. The relevant original records abstracted verify diagnosis according diagnostic criteria used in World Organization multinational monitoring trends determinants cardiovascular disease (MONICA) project. We compared incidence general population left- versus right-sided RESULTS: 2,128 median length follow-up 10.2 years. comparable that an age-matched women Ontario. There 70 coronary events among 56 irradiation. According MONICA criteria, 53 six characterized as definite possible MIs, respectively. Eleven did not satisfy MI. Twenty-six 23 experienced least one or (log-rank test, P = .66). eight MIs group group. no excess other cardiac diseases received radiotherapy CONCLUSION: have found evidence morbidity mortality from artery left BCS years follow-up. Longer is required confirm has been completely avoided.