Magnetic Resonance Imaging Captures the Biology of Ductal Carcinoma In Situ

• DOI: 10.1200/jco.2005.04.5518
• Publication Date: 2006-09-28T22:40:20Z
• Authors: Laura J. Esserman; Anjali S. Kumar; Alex F. Herrera; Jessica Leung; Alfred Au; Yunn-Yi Chen; Dan H. Moore; Daniel F. Chen; Jennifer Hellawell; Dulcy Wolverton; E. Shelley Hwang; Nola M. Hylton
• Keywords: Comedo; CD68

Purpose Magnetic resonance imaging (MRI) is an important tool for characterizing invasive breast cancer but has proven to be more challenging in the setting of ductal carcinoma situ (DCIS). We investigated whether MRI features DCIS reflect differences biology and pathology. Patients Methods Forty five 100 patients with biopsy-proven who underwent had sufficient tissue characterized by pathologic (nuclear grade, presence comedo necrosis, size, density disease) immunohistochemical (IHC) findings (proliferation, Ki67; angiogenesis, CD34; inflammation, CD68). Pathology (enhancement patterns, distribution, density) were analyzed using pairwise canonical correlations. Results Histopathologic IHC variables correlated (r = 0.73). The correlation was largely due (by either or pathology), inflammation (P < .05). Most small focal masses estrogen receptor-positive. enhancement patterns that clumped likely than heterogeneous high-grade lesions. Homogenous lesions large, high rich macrophages. Presence necrosis size could distinguished on most over-represent less dense, diffuse Conclusion presentation reflects underlying histopathologic differences.