Late Side Effects of Short-Course Preoperative Radiotherapy Combined With Total Mesorectal Excision for Rectal Cancer: Increased Bowel Dysfunction in Irradiated Patients—A Dutch Colorectal Cancer Group Study

• DOI: 10.1200/jco.2005.14.779
• Publication Date: 2005-08-31T03:31:37Z
• Authors: K.C.M.J. Peeters; C.J.H. van de Velde; J.W.H. Leer; H. Martijn; J.M.C. Junggeburt; E. Klein Kranenbarg; W.H. Steup; T. Wiggers; H.J. Rutten; C.A.M. Marijnen
• Keywords: Adult; Male; CARCINOMA; CURATIVE SURGERY; IMPACT; NETHERLANDS; LOCAL RECURRENCE; MULTICENTER RANDOMIZED-TRIAL; 03 medical and health sciences; UMCN 1.5: Interventional oncology; STANDARD; 0302 clinical medicine; Humans; Radiation Injuries; Aged; Aged, 80 and over; Rectal Neoplasms; ADENOCARCINOMA; Middle Aged; Combined Modality Therapy; Neoadjuvant Therapy; 3. Good health; ONCOL 3: Translational research; Patient Satisfaction; SURVIVAL; Female; Dose Fractionation, Radiation; Morbidity; Fecal Incontinence; Follow-Up Studies

Preoperative short-term radiotherapy improves local control in patients treated with total mesorectal excision (TME). This study was performed to assess the presence and magnitude of long-term side effects preoperative 5 x Gy TME. Also, hospital treatment recorded for diseases possibly related late rectal cancer treatment.Long-term morbidity assessed from prospective randomized TME trial, which investigated efficacy before surgery mobile cancer. Dutch without recurrent disease were sent a questionnaire.Results obtained 597 patients, median follow-up 5.1 years. Stoma function, urinary rates did not differ significantly between arms. However, irradiated compared nonirradiated reported increased fecal incontinence (62% v 38%, respectively; P < .001), pad wearing as result (56% 33%, anal blood loss (11% 3%, = .004), mucus (27% 15%, .005). Satisfaction bowel function lower impact dysfunction on daily activities greater who underwent alone.Although results control, there is more than undergo alone. Rectal should be informed both Future strategies aimed at selecting are high risk failure.