Risk of New Primary Nonbreast Cancers After Breast Cancer Treatment: A Dutch Population-Based Study

• DOI: 10.1200/jco.2007.11.9081
• Publication Date: 2008-03-06T23:24:26Z
• Authors: Michael Schaapveld; Otto Visser; Marieke J. Louwman; Elisabeth G.E. de...; Pax H.B. Willemse; Renée Otter; Winette T.A. van ...; Jan-Willem W. Coe...; Flora E. van Leeuwen
• Keywords: Cumulative incidence; Standardized mortality ratio

To assess the risk of secondary nonbreast cancers (SNBCs) in a recently treated population-based cohort breast cancer patients focused on association with treatment and prognostic implications.In 58,068 Dutch diagnosed invasive between 1989 2003, SNBC was quantified using standardized incidence ratios (SIRs), cumulative incidence, Cox regression analysis, adjusted for competing risks.After median follow-up 5.4 years, 2,578 SNBCs had occurred. Compared female population at large, this cohort, SIR increased (SIR, 1.22; 95% CI, 1.17 to 1.27). The absolute excess 13.6 (95% 9.7 17.6) per 10,000 person-years. SIRs were elevated esophagus, stomach, colon, rectum, lung, uterus, ovary, kidney, bladder cancers, soft tissue sarcomas (STS), melanoma, non-Hodgkin's lymphoma, acute myeloid leukemia (AML). 10-year 5.4% 5.1% 5.7%). Among younger than 50 radiotherapy associated an lung (hazard ratio [HR] = 2.31; 1.15 4.60) chemotherapy decreased all (HR 0.78; 0.63 0.98) colon cancer. age years older, raised STS 3.43; 1.46 8.04); risks uterine cancer, AML; hormonal therapy combined 1.10; 1.01 1.21) 1.78; 1.40 2.27). An worsened survival 3.98; 95%CI 3.77 4.20).Breast 1990 s experienced small but significant developing SNBC.