Association of Serum Interleukin-7 Levels With the Development of Acute Graft-Versus-Host Disease

• DOI: 10.1200/jco.2008.17.1314
• Publication Date: 2008-11-11T02:37:27Z
• Authors: Robert M. Dean; Terry Fry; Crystal Mackall; Seth M. Steinberg; Fran Hakim; Daniel Fowler; Jeanne Odom; Jason Foley; Ronald Gress; Michael R. Bishop
• Keywords: Adult; Male; 0301 basic medicine; CD3 Complex; CD8 Antigens; Histocompatibility Testing; Interleukin-7; Hematopoietic Stem Cell Transplantation; Graft vs Host Disease; Middle Aged; CD4 Lymphocyte Count; 3. Good health; 03 medical and health sciences; HLA Antigens; Predictive Value of Tests; Acute Disease; Living Donors; Humans; Female; Prospective Studies; Biomarkers; Immunosuppressive Agents; Aged

Morbidity from acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic stem-cell transplantation (HSCT) to treat malignancy. Interleukin-7 (IL-7), principal homeostatic cytokine for T cells, is required GVHD in murine models. In contrast inflammatory cytokines (eg, IL-2, tumor necrosis factor alpha), IL-7 has not been studied extensively clinical transplant setting relative its relationship with GVHD.We evaluated association serum levels 31 patients who were uniformly treated a prospective trial reduced-intensity HSCT human leukocyte antigen-identical siblings. prophylaxis consisted cyclosporine and methotrexate. Serum lymphocyte populations determined at enrollment, day before allograft infusion, specified intervals through 12 months post-transplantation.As expected, inversely correlated T-cell (P < .00001). Acute was significantly associated higher +7 = .01) +14 .00003) post-transplantation as well CD34(+) cell dose .01). also severity .0001). logistic regression models, these factors highly sensitive (up 86%) specific (100%) classifying whether developed GVHD.These data support preclinical observations that plays critical role inducing provide rational basis novel approaches prevent modulation pathway.