Prognostic factors in patients with WHO grade 3 gliomas: The Cleveland Clinic experience.

• DOI: 10.1200/jco.2011.29.15_suppl.2053
• Publication Date: 2017-02-23T18:58:03Z
• Authors: N. Hashemi-Sadraei; H. S. Bawa; A. Satra; G. Rahmathulla; M. Patel; G. Stevens; T. M. Tekautz; L. A. Rybicki; D. M. Peereboom; J. H. Suh; R. Weil; M. A. Vogelbaum; G. Barnett; M. S. Ahluwalia
• Keywords: Anaplastic astrocytoma

2053 Background: Anaplastic astrocytoma (AA), anaplastic oligodendroglioma (AO), and oligoastrocytoma (AOA) are the major histological categories of WHO grade 3 gliomas. Most randomized trials pool both grades or IV gliomas in their analysis. Consequently, there is limited data on specific prognostic factors for patients (pts) with Methods: After obtaining IRB approval, Cleveland Clinic Brain Tumor Neuro-Oncology Center’s database was used to identify pts histologically confirmed glioma at time diagnosis. Multivariable analysis conducted use a Cox proportional hazards model stepwise selection algorithm that p<.10 as criteria entry p<0.05 retention independent predictors survival. Results: Chart records 336 (52% whom were men) diagnosed between 1994 2009 included The median age presentation 50 years (range, 1-88 years). 49% had biopsy only, 21% gross total resection (GTR), 5% near (NTR), 25% subtotal (STR). Following surgery, 92% underwent radiation 62% concurrent chemotherapy. Median overall survival (OS) AA, AOA, AO 17.0 months, 58.7 months 74.2 respectively. OS all 25.9 months. Five identified survival, diagnosis (p<0.001), Karnofsky Performance Status histology (AA vs. AO, p<0.001), multifocal disease (p=0.012) type surgery (GTR biopsy, p<0.001). Conclusions: Older age, poor performance status, AA AOA histology, associated higher mortality. GTR STR, relative lower Risk mortality: Variable Hazard ratio 95% Confidence interval P value Age Per 10-year increase 1.39 1.22-1.58 <0.001 KPS 30-60 90-100 2.66 1.53-4.62 70-80 1.99 1.42-2.79 Histology Astro oligo 3.28 2.06-5.22 Mixed 2.23 1.24-4.04 0.008 Lesion Multifocal unifocal 2.87 1.26-6.58 0.012 Degree 0.39 0.25-0.63 NTR 0.44 0.19-1.03 0.06 STR 0.58 0.38-0.90 0.015