The effect of Cockcroft-Gault (CG) measurement of GFR on carboplatin dosage in ovarian cancer patients compared with Cr51-EDTA.

• DOI: 10.1200/jco.2011.29.15_suppl.e15538
• Publication Date: 2017-02-23T13:58:03Z
• Authors: M. Okera; J. Peacock; A. Hobinchetti; A. Montes
• Keywords: Carboplatin

e15538 Background: The accepted gold standard for carboplatin dose calculation is the Calvert formula: Dose = (GFR + 25) x AUC. GFR (glomerular filtration rate) commonly made with formulae such as CG, which are based on serum creatinine. Cr51-EDTA, a radionuclide scan, also can be used to calculate and more accurate closest estimation inulin clearance (gold GFR). impact of factors body mass index (BMI), muscle albumin upon accuracy CG versus EDTA not well-defined. Many international clinical trials correct AUC higher level when formula applied. Methods: Identification patients from local gynaecology-oncology database undergoing carboplatin-based chemotherapy ovarian cancer, all whom had Cr51-EDTA between January 2008 2011. Evaluation BMI, albumin, creatinine disease status prior chemotherapy. Comparison theoretical Carboplatin doses formula, termed Dose-EDTA Dose-CG respectively. Results: 58 patients,mean age 61 years (range 31-81), mean BMI 27.8 (17.95-48.01). Mean 40g/L (25-50) 66umol/L (35-139). dose-CG exactly matched in only 1 patient (1.7%) over-estimated 49 (84.5%), over-estimation by ≥10% 63.7% ≥30% 32.7%. underestimated 13.8%, underestimation 5.2%. Bland-Altman analysis showed that increased average increased. Multifactorial underway identify at risk will presented meeting. Conclusions: dosing measurement frequently inaccurate significantly overestimates compared Cr51-EDTA. practice increasing one using lead significant overdosage most cancer should Where facilities available, consideration given routine use dosage.