CHEK2*1100delC Heterozygosity in Women With Breast Cancer Associated With Early Death, Breast Cancer–Specific Death, and Increased Risk of a Second Breast Cancer

• DOI: 10.1200/jco.2012.42.7336
• Publication Date: 2012-10-30T05:50:03Z
• Authors: Maren Weischer; Børge G. Nordestg...; Paul Pharoah; Manjeet K. Bolla; Heli Nevanlinna; Laura J. van't Veer; Montserrat Garcia...; John L. Hopper; Per Hall; Irene L. Andrulis; Peter Devilee; Peter A. Fasching; Hoda Anton-Culver; Diether Lambrechts; Maartje Hooning; Angela Cox; Graham G. Giles; Barbara Burwinkel; Annika Lindblom; Fergus J. Couch; Arto Mannermaa; Grethe Grenaker A...; Esther M. John; Thilo Dörk; Henrik Flyger; Alison M. Dunning; Qin Wang; Taru A. Muranen; Richard van Hien; Jonine Figueroa; Melissa C. Southey; Kamila Czene; Julia A. Knight; Rob A.E.M. Tollenaar; Matthias W. Beckmann; Argyrios Ziogas; Marie-Rose Christ...; Johanna Margriet ...; Malcolm W.R. Reed; Gianluca Severi; Frederik Marme; Sara Margolin; Janet E. Olson; Veli-Matti Kosma; Vessela N. Kriste...; Alexander Miron; Natalia Bogdanova; Mitul Shah; Carl Blomqvist; Annegien Broeks; Mark Sherman; Kelly-Anne Phillips; Jingmei Li; Jianjun Liu; Gord Glendon; Caroline Seynaeve; Arif B. Ekici; Karin Leunen; Mieke Kriege; Simon S. Cross; Laura Baglietto; Christof Sohn; Xianshu Wang; Vesa Kataja; Anne-Lise Børrese...; Andreas Meyer; Douglas F. Easton; Marjanka K. Schmidt; Stig E. Bojesen
• Keywords: CHEK2

We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific and a second cancer in women first cancer.From 22 studies participating Breast Cancer Association Consortium, 25,571 white invasive were genotyped for observed up to 20 years (median, 6.6 years). examined death by estrogen receptor status after prospective studies.CHEK2*1100delC was found 459 patients (1.8%). In receptor-positive cancer, multifactorially adjusted hazard ratios heterozygotes versus noncarriers 1.43 (95% CI, 1.12 1.82; log-rank P = .004) 1.63 1.24 2.15; < .001) death. all women, ratio 2.77 2.00 3.83; increasing 3.52 2.35 5.27; only.Among 1.4-fold 1.6-fold 3.5-fold cancer. This one few examples genetic factor influences long-term prognosis being documented an extensive series