Comparison of lymph node staging system in gastric cancer using time-dependent ROC analysis with Harrell’s concordance index.

• DOI: 10.1200/jco.2013.31.4_suppl.12
• Publication Date: 2017-02-24T11:14:11Z
• Authors: Etsuro Bando; Norihiko Sugisawa; Masanori Tokunaga; Yutaka Tanizawa; Taiichi Kawamura; Yusuke Kinugasa; Hideyuki Kanemoto; Katsuhiko Uesaka; Masanori Terashima
• Keywords: Concordance; Grading (engineering)

12 Background: The aim this study was to clarify what the most informative pathologic lymph node staging system in gastric cancer is, by using time-dependent receiver operating characteristic (ROC) analysis with Harrell’s concordance (c) index. Methods: This enrolled 2747 primary patients, without prior chemotherapy, who underwent R0 or R1 macroscopically curative resection. We calculated indices of different 3 nodal systems (anatomical level based on JPN 13th edition vs. numbers metastatic nodes upon TNM 7th ratio nodes; derived from Yu’s definition {Yu et al. Br J Surg;1997,N0:0, N1;0-0.1, N2;0.1-0.25, N3;0.25-}) for survival. Results: (Anatomical level) c-index 0.754 5-year survival rate N0; 93%, N1; 73%, N2; 51%, N3; 19%. C-index node-negative patients 0.628. (Numbers positive nodes) 0.767 81%, 68%, 37%. 0.669. (Ratio involvement) 0.770 80%, 63%, 29%. 0.691, which is significantly larger than those anatomical (p<0.001, p=0.014, respectively). (Comparison Staging System) If combined pT category grading pStage IA, new (c-index; 0.760) 0.735) 0.742) (p=0.009, p=0.023, Conclusions: Lymph conception location nodes. These results suggested that next classification should include