IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma

• DOI: 10.1200/jco.2014.55.9880
• Publication Date: 2015-03-10T02:42:27Z
• Authors: Jessica L. Bell; Raseswari Turlapati; Tao Liu; Johannes H. Schulte; Stefan Hüttelmaier
• Keywords: Time Factors; Messenger; Medizin; Gene Dosage; 32 Biomedical and Clinical Sciences; Kaplan-Meier Estimate; anzsrc-for: 1103 Clinical Sciences; Neuroblastoma; Risk Factors; Databases, Genetic; Cancer; Oligonucleotide Array Sequence Analysis; Pediatric; Oncogene Proteins; N-Myc Proto-Oncogene Protein; 0303 health sciences; Tumor; RNA-Binding Proteins; Nuclear Proteins; Gene Expression Regulation, Neoplastic; Treatment Outcome; Phenotype; 570; Pediatric Cancer; 610; Transfection; Disease-Free Survival; Cell Line; Databases; 03 medical and health sciences; Rare Diseases; anzsrc-for: 32 Biomedical and Clinical Sciences; Genetic; Cell Line, Tumor; Genetics; Biomarkers, Tumor; Humans; Genetic Predisposition to Disease; Neoplasm Staging; Proportional Hazards Models; anzsrc-for: 3211 Oncology and Carcinogenesis; Neoplastic; Gene Expression Profiling; Neurosciences; anzsrc-for: 1112 Oncology and Carcinogenesis; Gene Amplification; Infant; 3211 Oncology and Carcinogenesis; Gene Expression Regulation; RNA; Biomarkers

Chromosomal 17q21-ter gain in neuroblastoma is both a common and prognostically significant event. The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) gene located near the proximal edge of this region. Here, its prognostic value evaluated neuroblastoma.The mRNA expression IGF2BP family members was first by microarray data sets. In addition, separate cohort 69 tumors, IGF2BP1 copy number, mRNA, abundance were determined compared with clinical parameters.In two independent sets, 77% to 100% tumors had substantial levels measured. High transcript significantly associated stage 4 (P < .001) decreased patient survival .001). also MYCN amplification abundance. samples, DNA number (increased 84% tumors), higher tumors. Importantly, lower overall = .012) positively correlated even when excluding MYCN-amplified Moreover, clearly affected cell vitro.In neuroblastoma, expressed majority specimens analyzed These demonstrate that potential oncogene an negative factor neuroblastoma.