Assessing performance status and clinical outcomes with wearable activity monitors.

• DOI: 10.1200/jco.2017.35.15_suppl.6571
• Publication Date: 2018-09-06T15:47:44Z
• Authors: Gillian K. Gresham; Elad Neeman; Andrew Eugene Hen...; Quanlin Li; Richard Tuli; Bj Rimel; Christine S. Walsh; Brennan Spiegel; Robert A. Figlin; Steven Piantadosi; Arvind Manohar Sh...
• Keywords: Performance status; Medical record

6571 Background: Performance status (PS) is assessed to inform treatment decisions and predict outcomes in cancer. PS often evaluated using ECOG or KPS scales, limited by their subjective static nature. Wearable activity monitors provide oncologists with the opportunity obtain continuous objective data on patients’ daily including steps, stairs climbed, sleep. We association between wearable monitor data, PS, clinical outcomes. Methods: Patients advanced cancer were enrolled a prospective, observational study conducted at Cedars-Sinai Medical Center. wore Fitbit Charge HR for 3 consecutive clinic visits. ECOG/KPS rated treating physicians serious adverse events (AE, clinically relevant grade 3+ CTCAE v4), hospitalizations, 6-month survival collected. Correlations metrics calculated. Multivariable regression models fit AEs hospitalizations data. The time death was analysis. Results: 35 patients (median age 62 years, 53% male) evaluated. Most had gastrointestinal cancers (82%). of 0 (20%), 1 (40%), 2 (23%), 3(17%). There 10 (29%) pts AEs, 14 (40%) 11 (31%) deaths. Average steps significantly correlated (r=0.73 0.70, respectively). Relationships metrics, overall (OS) are displayed table below. Conclusions: found significant risk hospitalization death. strong correlation step counts KPS/ECOG PS. potential supplement assessment should be explored future studies. Clinical trial information: NCT02659358. [Table: see text]