Human papillomavirus genotype and prognosis of invasive cervical cancer: A nationwide cohort study.

• DOI: 10.1200/jco.2019.37.15_suppl.5525
• Publication Date: 2019-05-27T16:09:53Z
• Authors: Jiayao Lei; Alexander Ploner; Camilla Lagheden; Carina Eklund; Sara Nordqvist Kl...; Bengt Andrae; Klara Miriam Elfs...; Joakim Dillner; Pär Sparén; Karin Sundström
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

5525 Background: The role of human papillomavirus (HPV) in development from oncogenic infection to invasive cervical cancer (ICC) has been well established. However, the association HPV genotypes and prognosis ICC is controversial. Methods: We identified all diagnosed Sweden during years 2002-2011 (4254 confirmed cases after clinical histo-pathological review), requested archival formalin-fixed, paraffin-embedded blocks subjected them comprehensive genotyping. Twenty out twenty-five archives agreed study, contributing a total 2845 with valid results. Cases were followed up date diagnosis 31 December, 2015, migration Sweden, or death; whichever occurred first. Five-year relative survival ratios (RSRs) calculated excess hazard (EHRs) 95% confidence intervals (CIs) estimated using Poisson regression. Results: was detected 2365 tumors (83.1% cases). five-year RSR by tumor status 0.54 (HPV negative), 0.76 (HPV16 positive), 0.73 (HPV18 0.72 (other high-risk positive) 0.56 (low-risk compared age-matched general female population. Compared HPV-negative tumor, significantly lower mortality seen if positive for HPV16 (EHR:0.54, CI 0.44-0.65), other (EHR:0.47, 0.37-0.60), low-risk (EHR:0.48, 0.32-0.74), adjustment age, time since diagnosis, International Federation Gynecology Obstetrics (FIGO) stage, educational level histology. among women HPV18 not statistically different tumors. In single either HPV18, those HPV18-positive had 56% (EHR:1.56, CI: 1.13-1.97) higher HPV16-positive Conclusions: genotype associated ICC. Single positivity indicated poorer than positivity. This could add information value beyond established prognostic factors