Prognostic role of PD-L1 expression in patients with advanced renal cell carcinoma (RCC) treated with sunitinib.

• DOI: 10.1200/jco.2019.37.7_suppl.603
• Publication Date: 2019-03-07T21:29:32Z
• Authors: Clara Iglesias; Rodrigo Ignacio C...; Lucía Rodríguez A...; Felipe Jose Alvar...; Verónica Blanco L...; Laura Faez; Maria Pilar Solis...; Sara Fernández; Alfonso Revuelta; David Gómez; Jorge del Río Fer...; Sena Valcárcel Go...; Debora Corina Con...; Luka Mihic Góngora; Emilio Esteban
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

603 Background: the prognosis and treatment of advanced RCC has improved over last decade due to a number effective anti-angiogenic immune checkpoint inhibitors (ICPI) therapies. Certain clinical factors, such as low Karnofsky status (≤ 70%); less than one year period from diagnosis administration; serum hemoglobin; high corrected calcium; lactate dehydrogenase; elevated neutrophil count or platelet exceeding upper limit normal range, have been able stratify patients into three distinct prognostic groups: favorable (zero risk factors), intermediate (one two), poor (more two). Nowadays, relationship between PD-L1 expression with response survival rate is current topic interest. Methods: retrospective analysis 182 who received sunitinb in single Institution conducted aim analyzing factor. To carry out immunohistochemical analysis, microscopy samples treated IHC 22C3 pharmDx assay, which intended measure percentage primary tumor tissue. Results: total 65 tissue sampling, were never (ICPI), analyzed. Among these, 95% considered 47% had expression. The results shown that associated worse progression-free (PFS) overall (OS). In no PD-L1, median PFS was 16.89 months (95% confidence interval 11.0 – 40.87 months) 12.61 for those some % (4.43 53.09). (χ² = 1.16; Pr > χ² 0.20). Likewise, OS 42.28 (13.76 68.13) 24.60 (13.76- not reached) ( χ ² 0.12; 0.73). Conclusions: sunitinib express shorter OS. Its validation an independent factor, regard other standard parameters, must be order develop more tailored approach decision.