Associations of a breast cancer polygenic risk score with tumor characteristics and survival.

Oncology and Carcinogenesis Clinical Sciences 610 Breast Neoplasms 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Risk Factors Breast Cancer Genetics Humans Oncology & Carcinogenesis Breast 10. No inequality Cancer Proportional Hazards Models Biomedical and Clinical Sciences Breast Cancer Association Consortium and MINDACT Collaborators Prevention Human Genome Oncology and carcinogenesis Prognosis 3. Good health Good Health and Well Being Women's Health Female
DOI: 10.1200/jco.2022.40.16_suppl.563 Publication Date: 2022-06-06T15:51:47Z
ABSTRACT
563 Background: A polygenic risk score (PRS) consisting of 313 single nucleotide polymorphisms (PRS ) is associated with breast cancer and contralateral cancer. One the most promising clinical applications for use PRS to provide a personalized assessment individualize screening programs. This study aimed evaluate association clinical-pathological characteristics survival Methods: Women European ancestry invasive were included, 98,397 women from Breast Cancer Association Consortium (BCAC) 683 MINDACT trial. Associations between (continuous, per SD) characteristics, including 70-gene signature patients included in MINDACT, evaluated logistic regression analyses. overall (OS), cancer-specific (BCSS) distant metastasis-free interval (DMFI) Cox analyses, adjusted treatment. Results: The was favorable tumor characteristics. In BCAC, increasing mostly lower grade, hormone receptor-positive tumors, smaller size. low signature, but attenuated after adjustment univariable analyses showed an better survival, hazard ratio (HR) unit SD increase OS: 0.96 (95% confidence (CI): 0.94-0.97), BCSS HR: CI: 0.94-0.98) DMFI 0.98 0.96-1.00). unadjusted analysis explained by differences (and treatment) disappeared adjustment: OS 1.01 0.98-1.05), 1.02 0.98-1.07) 1.03 0.99-1.07). Conclusions: An increased not independently prognosis. information crucial input modelling effective stratified programs, especially current era optimized (systemic) treatments. Given significant , absolute mortality will still be higher .
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