Associations of a breast cancer polygenic risk score with tumor characteristics and survival.
Oncology and Carcinogenesis
Clinical Sciences
610
Breast Neoplasms
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Risk Factors
Breast Cancer
Genetics
Humans
Oncology & Carcinogenesis
Breast
10. No inequality
Cancer
Proportional Hazards Models
Biomedical and Clinical Sciences
Breast Cancer Association Consortium and MINDACT Collaborators
Prevention
Human Genome
Oncology and carcinogenesis
Prognosis
3. Good health
Good Health and Well Being
Women's Health
Female
DOI:
10.1200/jco.2022.40.16_suppl.563
Publication Date:
2022-06-06T15:51:47Z
AUTHORS (17)
ABSTRACT
563 Background: A polygenic risk score (PRS) consisting of 313 single nucleotide polymorphisms (PRS ) is associated with breast cancer and contralateral cancer. One the most promising clinical applications for use PRS to provide a personalized assessment individualize screening programs. This study aimed evaluate association clinical-pathological characteristics survival Methods: Women European ancestry invasive were included, 98,397 women from Breast Cancer Association Consortium (BCAC) 683 MINDACT trial. Associations between (continuous, per SD) characteristics, including 70-gene signature patients included in MINDACT, evaluated logistic regression analyses. overall (OS), cancer-specific (BCSS) distant metastasis-free interval (DMFI) Cox analyses, adjusted treatment. Results: The was favorable tumor characteristics. In BCAC, increasing mostly lower grade, hormone receptor-positive tumors, smaller size. low signature, but attenuated after adjustment univariable analyses showed an better survival, hazard ratio (HR) unit SD increase OS: 0.96 (95% confidence (CI): 0.94-0.97), BCSS HR: CI: 0.94-0.98) DMFI 0.98 0.96-1.00). unadjusted analysis explained by differences (and treatment) disappeared adjustment: OS 1.01 0.98-1.05), 1.02 0.98-1.07) 1.03 0.99-1.07). Conclusions: An increased not independently prognosis. information crucial input modelling effective stratified programs, especially current era optimized (systemic) treatments. Given significant , absolute mortality will still be higher .
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