Cholangiocarcinoma: A nationwide trend analysis from 2016 to 2020.

• DOI: 10.1200/jco.2023.41.16_suppl.e16177
• Publication Date: 2023-06-04T15:38:35Z
• Authors: Michelle Ishaya; Rafaella Litvin; Chun-Wei Pan; Muhammad Bilal Ib...; Mihir Shah
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

e16177 Background: Cholangiocarcinomas (CCAs) are epithelial malignancies arising from the biliary ductal system, occurring with an incidence of 1/100,000 people per year in US. Most patients present advanced-stage disease and prognosis is very poor, five-year mortality rates ranging 2-24% depending on stage subtype. This study was designed to determine trends adverse outcomes CCA. Methods: retrospective trend analyzes data Nationwide Inpatient Sample (NIS) for years 2016-2020 identify adult hospitalizations a diagnosis cholangiocarcinoma highlight epidemiological trends. mortality, mean length stay (LOS), total hospital charge (THC), procedures complications were estimated. Multivariate regression analysis used assess statistical significance adjust confounders. Results: There increase number CCA 8.49/100,000 2016 11.0/100,000 2020 (p < 0.01). Mean age remained around 67 old, male predominance constant throughout this period (52.7%). White made up majority population (65.6%). ranged 6.8% 7.1%, no statistically significant trend. However, there THC (P-trend <0.05) change LOS 0.76). We found decrease endoscopic retrograde cholangiopancreatographies (ERCPs) performed (1.6% 1.2%, p=0.05), duct stents placed (1.2% 0.6%, p=0.003), percutaneous tract drains (4.2% 3.4%, p=0.002) 2020. An seen acute kidney injury (AKI) (22.9% 28.6%, P<0.05), stent-related (2.0% 2.6%, P=0.01), peritoneal metastasis (7.7% 9.3%, P<0.05). Biliary obstruction, infection, palliative care utilization did not show any during time. Conclusions: increased Demographics unchanged, stable inpatient rate but THC. The use ERCPs, stents, drainage devices decreased, AKI, complications, increased. It unclear what factors led decreased procedure complication rates. No changes observed infections, or utilization.[Table: see text]