Additional cycles of docetaxel in combination with androgen deprivation therapy (D-ADT) in metastatic hormone-sensitive prostate cancer (mHSPC): Efficacy and feasibility analysis.

• DOI: 10.1200/jco.2023.41.16_suppl.e17074
• Publication Date: 2023-06-04T15:53:48Z
• Authors: Can Aydogdu; Florian Urban; Alexander Tamalunas; Elena Berg; Melanie Götz; Severin Rodler; Lena Unterrainer; Volker Heinemann; Christian G. Stief; Jozefina Casuscelli
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

e17074 Background: Several phase III trials have assessed efficacy and safety of 6 cycles docetaxel combined to androgen deprivation therapy (D-ADT) in metastatic hormone-sensitive prostate cancer (mHSPC). This is the current standard care for a subgroup patients. We aimed assess whether treatment beyond prove be more effective than care. Methods: retrospectively collected data from patients with histologically confirmed adenocarcinoma radiologically proven disease treated at large tertiary center. All mHSPC were first-line D-ADT (75 mg/m 2 ) intravenously on first day each 21-day cycle. A subset was cycles. Clinical pathological variables examined, as treatment-related toxicities; progression free survival (PFS1), subsequent (PFS2) overall (OS) calculated start or death by log-rank test. Results: Between 2015-2023 total 108 observed median time 13.8 months. Mean age 66.2 years (range 46.9-82.7), 75.0% had GS≥8, 65.7% CHAARTED high-volume 69.4% LATITUDE high risk disease. 72 pts. ≤ (D-ADTstand) (4.2% 1-2 cycles; 95.8 % ≥3 mean 5.2 cycles) 36 > (D-ADTadd) (27.8% 7-8 72.2% ≥9-10 cycles, 9.2 cycles). Frequency toxicities did not differ groups. No significant differences PFS1 (10.3 vs. 13.4 mos.) PFS2 (6.3 6.6 mos.). Median OS D-ADTstand group 39.8 mos., D-ADTadd yet reached. Conclusions: While proved feasible without additional toxicity, superior compared Overall mature yet, but benefit chemotherapy upfront debatable leverages further studies light upcoming triplet combinations mHSPC, that presumably will render doublet obsolete future. [Table: see text]