Preoperative frailty to predict short-term outcomes in patients with cancer.

• DOI: 10.1200/jco.2023.41.4_suppl.810
• Publication Date: 2023-01-24T21:05:07Z
• Authors: Nazanin Khajouein...; Alison Buseck; Sayed Imtiaz; Yael Berger; Da Eun Cha; Eric Pletcher; Noah A Cohen; Benjamin Golas; Umut Sarpel; Spiros P Hiotis; Camilo Correa; Deepa Magge; Daniel M Labow
• Keywords: Depression

810 Background: Frailty is associated with increased postoperative complications. Despite multiple evidence-based modalities to assess frailty, surgeons often make subjective assessments of patients’ ability tolerate surgery. Identification those at risk poor outcomes particularly important in Surgical Oncology, as major resections may worsen debility and functional status, limiting the patients' receive further therapy. The Risk Analysis Index (RAI-C) a validated tool frailty surgical patients. It assigns points for any cancer diagnosis, potentially overestimating Oncology patients, has not been this subgroup. Methods: We performed prospective, surgeon-blinded study correlate results preoperatively administered survey predict short- long-term patients histologically proven malignancy who underwent RAI-C, Patient Health Questionnaire (PHQ9), General Anxiety Disorder (GAD) surveys were depression, anxiety, respectively; C-reactive protein (CRP), pre-albumin, albumin, hematocrit obtained. Outcomes, including readmission, complications, ICU admission, disposition (home vs rehabilitation/nursing facility), 1-year survival compared between different groups defined by lab results. Results: One hundred ninety-one included, which 135 considered frail based on predefined value (RAI-C ≥21). Frail more likely be readmitted within 30 days (14% 2%, P=0.01). No difference was found length stay, 90-day or disposition. Only 15.8% met criteria anxiety 11% depression. Measured similar anxious depressed. Patients abnormal pre-albumin levels require admissions (31% 8%, P <0.005), intubation (12% 0.02%, P=0.02), discharged facility other than home (19% 10%, Similar trends noted albumin also had longer lengths stay (mean 9.32 7.88 days, P=0.007). There an association improved normal CRP, levels. determined RAI-C decreased survival. Conclusions: that can used prescreening however score did morbidity, discharge disposition, Results from survey, well preoperative laboratory screening benefit optimization follow-up.