Prognostic utility of linear segmentation in nonmetastatic renal cell carcinoma: Correlation of overall survival with muscle mass.

• DOI: 10.1200/jco.2023.41.6_suppl.617
• Publication Date: 2023-03-14T15:22:32Z
• Authors: Benjamin Schmeusser; Eric Midenberg; Arnold Raul Palacios; Nikhil Vettikattu; Dattatraya H Patil; Reza Nabavizadeh; Alexandra Medline; Michelle Higgins; Sarah P. Psutka; Kenneth Ogan; Viraj A. Master

617 Background: In renal cell carcinoma (RCC) and other solid organ malignancies, sarcopenia has been associated with decreased survival increased perioperative complications. Traditional body composition analysis is an expensive time extensive process. As a modifiable risk factor, more clinic friendly methods to identify patients low muscle of interest. Linear segmentation on routine imaging proposed as fast, reliable reproducible alternative. This study assesses the prognostic ability linear in nonmetastatic RCC. Methods: Patients that underwent nephrectomy for RCC from 2005-2021 at academic referral center were identified. bilateral psoas/paraspinal muscles was completed preoperative obtained within 60 days surgery. Cox proportional-hazards used determine association between total index overall survival. Results: 532 (388 clear cell) analyzed median 28.6 (25.8-32.5) women 33.3 (29.1-36.9) men. binary variable, lower significantly both full (HR=1.96, 95% CI 1.32-2.90, p<0.001) only cohorts (HR=1.78, 1.08-2.75, p=0.022). continuous unit increases improved cohort (HR=0.95, 0.92-0.99, p=0.006) p=0.016). Conclusions: Assessment via routinely clinically feasible technique utility localized this RCC, demonstrated significant associations variable. simplified may allow inclusion into clinical decision making. [Table: see text]