Effects of Attractive Pickering emulsion gels loaded with oxaliplatin and lactate dehydrogenase inhibitors in hepatocellular carcinoma.

• DOI: 10.1200/jco.2024.42.16_suppl.e16235
• Publication Date: 2024-07-03T19:28:03Z
• Authors: Chanqi Ye; Ruyin Chen; Qiong Li; Shuaishuai Xu; Jian Ruan
• Keywords: Pickering emulsion

e16235 Background: Oxaliplatin (OXA) can be used as a palliative treatment for advanced hepatocellular carcinoma (HCC). While most patients still have rapid disease progression after OXA due to the drug resistance. The lactate dehydrogenase A (LDHA) inhibitors reduce inflammation-induced effects, metastasis, and proliferation potential of cancer cells. combination LDHA inhibitor may an effective HCC. Methods: We adopt water-in-oil attractive Pickering emulsion gel (APEG) deliver inhibitor, GSK2837808A (GSK). is dissolved in water GSK iodized oil. injected OXA+GSK@gel into peritumoral tissues subcutaneously tumorigenic HCC model mice, then observe tumor size. Next, we apply immunohistochemical staining terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay on dissected tumors explore cell apoptosis. Meanwhile, flow analysis applied investigate immune microenvironment Results: This drugs-loaded APEG has good biocompatibility release slowly. significant anti-tumor effect model, which effectively inhibit promote confirm that it could activate infiltration CD8 + T cells was increased, thereby providing better effect. Conclusions: results suggest APEGs loaded with improve delivery efficiency enhance therapy.