Effect of a multidisciplinary intervention based on a supervised training program on cardiovascular risk and quality of life in early stage breast cancer patients.

• DOI: 10.1200/jco.2025.43.16_suppl.545
• Publication Date: 2025-05-28T16:43:03Z
• Authors: Maria Torrente; Gorka Benitez; Pedro Da Costa Sousa; Enrique Colino; Beatriz Nuñez García; Margarita Diez; Miriam Mendez; Juan Cristobal Sa...; Marta Mendez; Esther Vielba; Eva Garcia-Zozaya; Mariano Provencio; Blanca Cantos

545 Background: There is growing evidence that physical activity can enhance cancer care. Exercise programs have been shown to help manage treatment side effects, improve functional outcomes, overall quality of life, and reduce fatigue. Additionally, obesity cardiovascular disease are among the most common comorbidities in breast survivors. However, despite these benefits, exercise still not widely prescribed oncology patients. A multidisciplinary approach involving various healthcare professionals crucial ensuring interventions tailored individual needs. Our study aims determine whether a 12-week intervention fitness risk patients with early-stage after completing oncologic treatment. For first time, impact assessed by measuring cardiorespiratory (VO₂ max) muscle strength, including range motion, speed, power. Methods: total 75 women histologically confirmed Stage I-III primary who recently completed all cancer-related treatments were included. Through computer-generated simple randomization, participants assigned resistance training (RTG; two sessions/week for 12 weeks) or control (CG; general guidelines recommendations). Outcomes evaluated at baseline week 12. Muscular strength ( power) was outcome. Secondary outcomes included (measured VO₂ max- maximum rate oxygen consumption attainable during exercise), fatigue HRQoL. All had Performance status 0 1 EUROQOL-5D 5L EORTC-QLQ-C30 QoL online survey. Results: The expected number enroled (mean age 55.9 ± 7.4 years, female). Patients significant positive change HRQoL score [mean difference 3.8; 95% confidence interval (CI) 0.2; 7.3; P = .038], body mass index −0.7 kg/m2 (95% CI −1.3; −0.1); .022], 2.5 0.1; 5); .044; effect size 0.39], (VO2 2.7 0.8; 4.6); .007]. No changes observed group between Conclusions: This supervised exercise-based programme improved HRQoL, index, power loads while notably enhancing fitness. Integrating into standard practice significantly patient's life risk.