Two decades of change: Tracking intrahepatic cholangiocarcinoma mortality in the United States from 1999 to 2020.

• DOI: 10.1200/jco.2025.43.16_suppl.e16197
• Publication Date: 2025-05-28T15:05:58Z
• Authors: Anoud Khan; Aryan Tareen; Syed Usama Ashraf; Imaan Shoaib Mufti; Maryam Karam; Fatima Ibrahim Ahmed; Syeda Neha Rasool; Rinad Akhtar; Ahrar Amin; Saqib Raza Khan
• Keywords: Intrahepatic Cholangiocarcinoma

e16197 Background: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy, recognized for its uncommon yet highly aggressive nature. In United States, incidence of ICC has been steadily rising, with a projected rise up to 99% expected by 2029. Correspondingly, overall mortality increasing in States over past two decades ICC. The 5-year survival rate remains very low at 9%, cases rising globally. Objective: This 21-year retrospective analysis aims study multifaceted nature ICC's growing and trends across U.S. from 1999 2020 stratifying demographic regional variables. Through comprehensive assessment various variables, our provides thorough understanding high-risk demographics associated ICC, aiming address disparities advocate policy planning ensure equitable access cancer care globe. Methods: data was abstracted CDC-WONDER 1999-2020. Age-Adjusted Mortality Rate (AAMR) per 100,000 population Annual Percentage Change (APC) along 95% confidence intervals (CI) were determined. Joinpoint regression employed examine groups. Results: A total 113,450 ICC-related deaths occurred between 2020. overall-ICC related AAMR increased 0.98 2.04 an APC 3.55. Males had higher (2.32) as compared females (1.83). Non-Hispanic (NH) Asian or Pacific Islander highest (2.61) 2019, (4.19) recorded NH-Black African American individuals. rates people aged 85+, (4.43) observed 45-54. Wisconsin, Minnesota, Connecticut, Washington, Hawaii, Rhode Island approximately double states that fell lower 10 th percentile. Large metropolitan (4.28) rural areas. Conclusions: continue alongside rate. Investigating contributing factors essential, conjunction outlined trends. Addressing can enhance early diagnosis treatment, improving public health outcomes. percent change age-adjusted intrahepatic 1000,000 States; (95% CI) Overall 3.55 1.13 2.32 3.35 Females 0.89 1.83 3.61 NH-Asian/Pacific 1.48 2.02 0.82 2.00 4.19 NH-White 2.01 3.54 Hispanic/Latino 1.20 2.05 2.93 Age 45-54 0.58 1.33 4.43 Metro 1.99 4.20 3.60