Temporal and regional mortality trends due to pulmonary embolism in patients with hematolymphoid malignancies in the United States from 1999 to 2020.

• DOI: 10.1200/jco.2025.43.16_suppl.e19087
• Publication Date: 2025-05-28T13:27:46Z
• Authors: Amna Mansoor; Ahsan Raza Raja; Muhammad Ahmad Na...; Fatima Naveed; Abdullah Ahmad; Mian Zahid Jan Ka...; Abdul Rafeh Awan; Muhammad Usman Ar...; Zain Ali Nadeem; Fatima Ashfaq; Mohamed Fawzi Hemida; Amir Sohail; Pranjal Singh

e19087 Background: Pulmonary embolism (PE) is a significant complication and marker of increased mortality in patients suffering from hematolymphoid malignancies, including leukemias, lymphomas, multiple myeloma. Individuals with these hematologic cancers are at an risk venous thromboembolism (VTE) due to cancer-associated hypercoagulability, treatment-related effects, disease-related factors. Examining trends critical for informing targeted interventions optimizing patient management. Methods: This retrospective study analyzes national data the CDC WONDER database assess 1999 2020 across different demographic subgroups United States. Patients known history cancer were identified PE related was retrieved. Age-adjusted rates (AAMRs) per 100,000 individuals calculated further stratified based on sex, age, race census region. Rstudio used perform t-test Mann Kendall test. Results: From 2020, total 12,453 deaths reported associated US (females, AAPC: 0.17 (95% CI: 0.165-0.175) vs. males 0.256 0.25-0.263)). The overall AAMR demonstrates general upward trend some annual fluctuations, increasing 0.409 1.022 2020. declined around 2009, reaching its nadir (τ: -0.160, p=0.321 females, τ: 0.105, p=0.516). 2010 onwards, gradual increase observed, sharp spike Men consistently had higher than women, 0.166 0.261 0.223 0.31 Black or African American females AAMRs (0.228) White (0.164). Males followed similar (0.356 0.261). also varied significantly by region, Midwest having highest rate (0.219), Northeast (0.214). For age group 16-64 years, (0.065), (0.034), 0.047 (p<0.001). Similar seen older 65 years (1.28 vs 0.819), which demonstrated (1.059) In summary, 65+ AAMR. Conclusions: Our analysis malignancy-associated pulmonary highlights concerning this near-fatal cancer-related complication, particularly after 2010, impact observed among male those residing These findings emphasize urgent need healthcare programs focus vulnerable populations implementing enhanced screening protocols, lowering diagnostic threshold malignancies.