A populational change in prognosis of patients diagnosed with locally advanced melanoma: Last glimpse before the introduction of adjuvant treatment in stage IIB/C.

• DOI: 10.1200/jco.2025.43.16_suppl.e21575
• Publication Date: 2025-05-28T21:07:36Z
• Authors: Pawel Teterycz; Katarzyna Kozak; Marcin Zietek; Marcin Zdzienicki; Magdalena Papiez; Grazyna Kaminska-...; Katarzyna Galwas; Natasza Kempa-Kam...; Bożena Cybulska-S...; Lukasz Galus; Robert Dziura; Dariusz Nejc; Kamil Drucis; Michal Jankowski; Joanna Placzke; Anna Mariuk-Jarema; Pawel Rogala; Jerzy W. Mitus; Hanna Kosela-Pate...; Piotr Rutkowski

e21575 Background: The treatment of early-stage melanoma is rapidly changing. Recent advancements include neoadjuvant in stage III clinically detected disease and adjuvant IIB/C melanoma. In particular, immunotherapy for has become recently available. We took this opportunity to evaluate changes outcomes patients diagnosed with II Methods: have analyzed the accessible, retrospective data on between 2015 2022 who underwent sentinel lymph node biopsy or therapeutic dissection high-throughput centers Poland. primary staging, patients’ demographics, information follow-up overall survival (OS) were collected. A prespecified OS Cox model non-linear terms age, sex, (II vs. III), availability (i.e., since 2021) was fitted. Results: There 1970 (45.2% female) included analysis. mean age 62 (range:14-97). exact distribution 3-year rates are presented Table 1. Patients before 2021 had worse prognoses than (HR: 1.33, 95%CI: 1.11-1.60, p=0.002). Since then prognosis did not improve 1.13, 0.89-1.45, p=0.325) while became similar after introduction therapy 1.09, 95% CI: 0.78-1.53, p = 0.607). Conclusions: improved nationwide study. modern without treatment, excellent results IIIA/IIIB cases. practitioners should be cautious when discussing historical their it implies necessity AJCC staging. Stage rates. Number Percentage group 3 year survial rate (%) Confidence Interval IIA 352 17.9 86.5 82.9 - 90.3 IIB 378 19.2 76.5 72.2 81.2 IIC 443 22.5 59.9 55.3 64.8 IIIA 84 4.3 94.3 89.1 99.9 IIIB 132 6.7 94.6 90.5 98.9 IIIC 518 26.3 68.5 64.3 73.1 IIID 63 3.2 53.3 42.2 67.4