Relationship between androgen deprivation therapy and kidney function in patients with prostate cancer: An analysis of the RADICAL-PC study.

• DOI: 10.1200/jco.2025.43.5_suppl.115
• Publication Date: 2025-02-18T14:38:27Z
• Authors: Geethan Baskaran; Jehonathan H. Pin...; Celestia S. Higano; Cristina Cano Garcia; Rajibul Mian; Germano Dallegrav...; Guila Delouya; Cesar O.L. Dusilek; Bobby Shayegan; Rafaela Kirchner ...; Tamim Niazi; Margot K. Davis; Avirup Guha; Joseph B. Selvana...; Jose Enrique Cita...; Patrick P. Luke; Darryl Leong
• Keywords: Kidney cancer

115 Background: Androgen deprivation therapy (ADT) is an effective treatment for patients with advanced prostate cancer (PC). However, its impact on renal function remains underexplored. We evaluated the of ADT kidney in a cohort PC. Methods: analyzed RADICAL-PC study (Role Androgen-Deprivation Therapy Cardiovascular Disease—A Longitudinal Prostate Cancer study, NCT04127631), prospective PC 10 countries. use was assessed at baseline and follow-up visits. quantified using glomerular filtration rate (GFR), calculated CKD-EPI equation creatinine measurements obtained annual used linear mixed-effects regression model to analyze association between change GFR (ΔGFR), adjusting age, diabetes, hypertension, disease, heart failure, chemotherapy, medications, alcohol use, smoking. Using Cox model, we acute injury (AKI) as reported by sites. Results: Our analysis included 4119 participants median age 68 (IQR 63-74) years. In 1791 (43%) baseline, ΔGFR over 2 years -0.64 [95%CI -1.05 -0.22] ml/min/1.73m /year. 2328 (57%) ADT-naïve -1.00 -1.34 -0.64] There no significant difference two groups (p=0.20). Age (β=-0.58, p<0.001), hypertension (β=-1.98, p<0.01), anticoagulation (β=-3.92, p<0.001) were associated decline. When time-varying covariate, less decline than (-0.21 vs. -1.07 /year, respectively, p<0.01). Duration not (+0.04 -0.02 0.10] /month, p=0.18). AKI developed 91 (2.2%) 25 12-36) months. Baseline increased risk univariate (HR 2.58 1.67 3.98], but after adjustment covariates 1.37 0.83 2.26], p=0.22). Conclusions: This suggests that or incidence PC, challenging previous literature concerning ADT-related dysfunction. Further studies longer periods are needed confirm these findings.