Impact of androgen deprivation therapy with postoperative radiotherapy after radical prostatectomy on health-related quality of life.

• DOI: 10.1200/jco.2025.43.5_suppl.133
• Publication Date: 2025-02-18T14:35:11Z
• Authors: Thilo Westhofen; Alexander Buchner; Lennert Eismann; Severin Rodler; Elena Berg; Can Aydogdu; Darjusch Askari; Armin Becker; Christian G. Stief; Alexander Kretschmer

133 Background: There is an ongoing debate on the use and duration of androgen deprivation therapy (ADT) with postoperative radiotherapy (RT) following radical prostatectomy (RP). While there have been conflicting results regarding oncological outcome, effect concomitant ADT health-related quality life (HRQOL) remains elusive. We aimed to assess impact adding RT long-term HRQOL by providing PROM data from a large contemporary cohort patients undergoing RP systematic follow-up up 10 yrs. Methods: n=1124 who underwent after previous at tertiary care center between 2010 2021 were identified within prospective institutional database. Patients post-op excluded. stratified (no n=682; n=436). PROMs prospectively assessed preoperatively, prior post maximum 120mo, applying validated EORTC QLQ-C30- prostate cancer-specific QLQ-PR25-questionnaires. Correlation analysis multivariable regression models used estimate HRQOL. Results: Median received ADT-cohort was 21mo. Prior RT, no significant difference in general global health status domain (GHS) found (69.6) (68.9; p=0.88). Post (65.1 vs. 69.9; p=0.038) median 59 months (62.8 68.1; p<0.001) reported significantly worse In age, BMI, pT-stage, urinary continence erectile functioning, confirmed as independent predictor for (OR 0.68, 95% CI 0.47-0.96, p=0.03). revealed correlation longer (p<0.001). line, linear independently predict (p=0.041) (Table). Conclusions: yields A furthermore leads Those support careful patient selection RP. Multivariable Variable B [regression coefficient] Beta [standardized SE [standard error] p value Duration -0.272 -0.191 0.132 0.041 Age -0.127 -0.043 0.294 0.667 BMI -0.588 -0.120 0.444 0.188 ICIQ-SF-Score 0.914 0.012 6.729 0.892 IIEF5-Score 0.661 0.165 0.403 0.103 R² 0.341 Adjusted 0.336