Heat Shock Protein 72 (HSPA1B) Gene Polymorphism and Toll-Like Receptor (TLR) 4 Mutation Are Associated with Increased Risk of Urinary Tract Infection in Children

• DOI: 10.1203/pdr.0b013e318030d1f4
• Publication Date: 2007-04-13T11:37:18Z
• Authors: Eva Karoly; Andrea Fekete; Nora F Banki; Beata Szebeni; Adam Vannay; Attila J Szabo; Tivadar Tulassay; Georg S Reusz
• Keywords: Male; Heterozygote; 0303 health sciences; Polymorphism, Genetic; Genotype; HSP72 Heat-Shock Proteins; Immunity, Innate; 3. Good health; Toll-Like Receptor 4; 03 medical and health sciences; Recurrence; Case-Control Studies; Child, Preschool; Mutation; Urinary Tract Infections; Humans; Female; Child; Alleles

Innate immunity and urinary tract response play a central role in the development of urinary tract infection (UTI). Heat shock protein (HSP) 72 and Toll-like receptor (TLR) 4 are among the key elements of innate defence mechanisms. This study assesses the role of HSPA1B A(1267)G and TLR4 A(896)G polymorphisms using allele-specific polymerase chain reaction in 103 patients treated with recurrent UTI. Allelic prevalence was compared with reference values of 235 healthy controls. Clinical data were also statistically evaluated. TLR4 (896)AG genotype and TLR4 (896)G allele had also higher prevalence in UTI patients versus controls (p = 0.031 and 0.041, respectively). Our data indicates a relationship between the carrier status of HSPA1B (1267)G and TLR4 (896)G alleles and the development of recurrent UTI in childhood independently of other renal abnormalities, while raising further questions about the clinical and therapeutic relevance of these polymorphisms in everyday pediatric nephrology.