The Role of the Vagal Nerve in Peripheral PYY3–36-Induced Feeding Reduction in Rats

• DOI: 10.1210/en.2004-1266
• Publication Date: 2005-02-18T01:18:30Z
• Authors: Shuichi Koda; Yukari Date; Noboru Murakami; Takuya Shimbara; Takeshi Hanada; Koji Toshinai; Akira Niijima; Mayumi Furuya; Norio Inomata; Kazuhiro Osuye; Masamitsu Nakazato
• Keywords: Nodose Ganglion; Solitary tract; Peptide YY; Solitary nucleus; Dorsal motor nucleus

Abstract Peptide YY (PYY), an anorectic peptide, is secreted postprandially from the distal gastrointestinal tract. PYY3–36, major form of circulating PYY, binds to hypothalamic neuropeptide Y Y2 receptor (Y2-R) with a high-affinity, reducing food intake in rodents and humans. Additional hormones involved feeding, including cholecystokinin, glucagon-like peptide 1, ghrelin, transmit satiety or hunger signals brain via vagal afferent nerve and/or blood stream. Here we determined role vagus PYY function. Abdominal vagotomy abolished effect PYY3–36 rats. Peripheral administration induced Fos expression arcuate nucleus sham-operated rats but not vagotomized We showed that Y2-R synthesized rat nodose ganglion transported terminals. stimulated firing gastric when administered iv. Considering present fibers, could directly alter rate Y2-R. also investigated ascending fibers solitary tract on transmission PYY3–36-mediated signals. In rats, bilateral midbrain transections rostral PYY3–36-induced reductions feeding. This study indicates peripheral may part pathway.